徐慧，博士，山東臨沂人

郵箱：xuhuiapchy@126.com

教育經曆

2016.09-2020.12，香港大學，食品與營養科學，博士

2012.09-2015.06，中國海洋大學，食品科學，碩士

2008.09-2012.06，中國海洋大學，生物科學（海洋生物學方向），學士

學術工作經曆

2024.07至今，伟德w88平台，專任教師

2023.05-2024.06，深圳大學，副研究員

2021.01-2023.04，深圳大學，博士後

研究方向

1. 膳食多酚的功效評價與分子機制解析

2. 藥食同源植物中功效因子的發掘及生物活性探究

項目情況

1. 柚皮素類黃烷酮化合物改善缺血性腦卒中損傷和神經再生功能的作用和機制研究，中國博士後科學基金面上項目，2021.01-2022.12，8萬元，主持

2. 柚皮素衍生物抑制神經炎症并改善腦缺血再灌注損傷的作用研究，中國博士後國（境）外交流項目——引進項目，2021.01-2022.12，40萬元，主持

3. 從腸道菌群角度解析陳皮黃酮對AGEs損傷的保護作用，廣東省基礎和應用基礎面上項目，2022.01-2024.12，10萬元，參與

代表性成果

1. Hui Xu, Shenglong Yu, Chunxi Lin, Dingjun Dong, Jianbo Xiao, Yanbin Ye, Mingfu Wang (2024), Roles of flavonoids in ischemic heart disease: cardioprotective effects and mechanisms against myocardial ischemia and reperfusion injury, Phytomedicine, 2024, 155409

2. Haoxie Xu, Yachao Wang, Xiangzhu Li, Xuli Wu, Louise Weiwei Lu, Jiayi He, Mingfu Wang, Bin Liu, Hui Xu*, Jie-Hua Chen*, Ka-Wing Cheng* (2024). β-1,3-glucan-rich Euglena gracilis supplementation alleviated high-fat-high-fructose diet-induced cognitive impairment in aged mice via gut-brain axis, Food Science and Human Wellness, in press

3. Hui Xu, Qian Zhou, Bin Liu, Feng Chen, Mingfu Wang (2022). Holothurian fucosylated chondroitin sulfates and their potential benefits for human health: Structures and biological activities. Carbohydrate Polymers, 275, 118691

4. Hui Xu, Jiangang Shen, Jianbo Xiao, Feng Chen, Mingfu Wang (2021). Neuroprotective effect of cajaninstilbene acid against cerebral ischemia and reperfusion damages by activating AMPK/Nrf2 pathway. Journal of Advanced Research, 34, 199–210

5. Hui Xu, Qian Zhou, Bin Liu, Ka-Wing Cheng, Feng Chen, Mingfu Wang (2021). Neuroprotective potential of mung bean (Vigna radiata L.) polyphenols in Alzheimer’s disease: A review. Journal of Agricultural and Food Chemistry, 69, 11554-11571

6. Hui Xu, Emily Wang, Feng Chen, Jianbo Xiao, Mingfu Wang (2021). Neuroprotective phytochemicals in experimental ischemic stroke: Mechanisms and potential clinical applications. Oxidative Medicine and Cellular Longevity, 2021, 6687386

7. Hui Xu, Ruixia Deng, Edmund T.S. Li, Jiangang Shen, Mingfu Wang (2020). Pinosylvin provides neuroprotection against cerebral ischemia and reperfusion injury through enhancing PINK1/Parkin mediated mitophagy and Nrf2 pathway. Journal of Functional Foods, 71, 104019

8. Hui Xu, Fei Wang, Jingfeng Wang, Jie Xu, Yuming Wang, Changhu Xue (2015). The WNT/β-catenin pathway is involved in the anti-adipogenic activity of cerebrosides from the sea cucumber Cucumaria frondosa. Food & Function, 6, 2396-2404

9. Hui Xu, Jingfeng Wang, Yaoguang Chang, Jie Xu, Yuming Wang, Tengteng Long, Changhu Xue (2014). Fucoidan from the sea cucumber Acaudina molpadioides exhibits anti-adipogenic activity by modulating the Wnt/β-catenin pathway and down-regulating the SREBP-1c expression. Food & Function, 5, 1547-1555

10. Hui Xu, Jingfeng Wang, Xin Zhang, Zhaojie Li, Yuming Wang, Changhu Xue (2015). Inhibitory effect of fucosylated chondroitin sulfate from the sea cucumber Acaudina molpadioides on adipogenesis is dependent on Wnt/β-catenin pathway. Journal of Bioscience and Bioengineering, 119, 85-91

11. Hui Xu, Jie Xu, Yiming Wang, Shiwei Hu, Yuming Wang, Jingfeng Wang, Changhu Xue (2015). Fucoidan isolated from the sea cucumber Acaudina molpadioides improves insulin resistance in adipocytes via activating PKB/GLUT4 pathway. European Food Research and Technology, 240, 753-761

12. Shiwei Hu^#, Hui Xu^#, Ruixi Chen, Jingfeng Wang, Zhaojie Li, Jiachao Xu (2014). Activation of PKB and ERK, but not PI3K, is involved in fucosylated chondroitin sulphate from Acaudina molpadioides induced glucose uptake. Journal of Functional Foods, 10, 385-396 (共同第一作者)

13. 徐慧，徐傑，趙延蕾，于哲，王靜鳳 (2017). 葉瓜參鞘脂抑制3T3-L1前脂肪細胞分化及構效關系研究. 中國食品學報，17, 17-22 (EI檢索)

14. 王明福，徐慧，周倩，陳峰，劉賓，鄭家榮. 黃烷酮類化合物及其制備方法和應用. 中國發明專利，已授權，ZL202210460239.1, 2023-09-22